MPNs are a gaggle of continual sicknesses of the hematopoietic stem cellular leading to overproduction of myeloid progenitor cells, together with white blood cells, crimson blood cells or platelets within the bone marrow. Credit score: Karolinska Institutet (2024). DOI: 10.69622/26983783.v1
A brand new thesis from Karolinska Institutet presentations the effectiveness of versatile parametric survival fashions in modeling a couple of time-scales, offering a strong device for advanced time-to-event knowledge evaluation. The fashions had been examined within the context of myeloproliferative neoplasms, a gaggle of continual hematologic malignancies by which the bone marrow makes too many crimson blood cells, white blood cells, or platelets.
This overproduction may end up in more than a few headaches, together with blood clots (thrombosis), bleeding issues, transformation to acute myeloid leukemia and myelodysplastic syndromes.
In her thesis, doctoral pupil Nurgul Batyrbekova on the Division of Clinical Epidemiology and Biostatistics, describes a singular strategy to modeling a couple of time-scales in time-to-event evaluation via the usage of versatile parametric survival fashions (FPM) that may seamlessly incorporate a couple of time-scales with out requiring knowledge splitting. She additionally explores whether or not conventional survival fashions that depend on a unmarried time-scale result in bias and inaccuracies in positive eventualities.
In two of her research, the usage of the radical means, Nürgul investigates clinically related questions for MPN, in particular, how the speed of thrombosis and the speed of transformation to AML/MDS are suffering from age and period of MPN illness.
Total, her thesis may display that the brand new means to make use of a couple of time-scales in survival fashions used to be higher and offers solutions to clinically related analysis questions within the box of MPN.
Additional information:
Nurgul Batyrbekova, Modelling a couple of time-scales with versatile parametric survival fashions : with programs to myeloproliferative neoplasms, (2024). DOI: 10.69622/26983783.v1
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A strong device for advanced time-to-event knowledge evaluation within the context of myeloproliferative neoplasms (2024, November 25)
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Publish date : 2024-11-25 21:52:09
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